Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nutrient consumption and metabolic perturbations

J C LaManna1, W D Lust

  • 1Department of Neurology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106-4938, USA.

Neurosurgery Clinics of North America
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies on the GABAergic system in astrocytoma and neuroblastoma cells in culture.

Neurochemical research·2013
Same author

Regional brain blood flow in mouse: quantitative measurement using a single-pass radio-tracer method and a mathematical algorithm.

Advances in experimental medicine and biology·2011
Same author

Distribution of NBCn2 (SLC4A10) splice variants in mouse brain.

Neuroscience·2010
Same author

Effect of alternate energy substrates on mammalian brain metabolism during ischemic events.

Advances in experimental medicine and biology·2008
Same author

Ultrastructural analysis of a murine model of congenital hydrocephalus produced by overexpression of transforming growth factor-beta1 in the central nervous system.

Journal of submicroscopic cytology and pathology·2007
Same author

Statistical analysis of metabolic pathways of brain metabolism at steady state.

Annals of biomedical engineering·2007
Same journal

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Spinal Cord Deformities Associated with Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Radiation Therapy for Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Treatment Strategies of Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Vascular Lesions of the Spinal Cord: Arteriovenous and Cavernous Malformations.

Neurosurgery clinics of North America·2026
Same journal

Hemangioblastomas of the Spinal Cord.

Neurosurgery clinics of North America·2026
See all related articles

The brain needs constant nutrients for energy and function. Brain attacks disrupt nutrient supply, causing damage, necessitating interventions to restore nutrient consumption and repair metabolic injury.

Area of Science:

  • Neuroscience
  • Metabolism
  • Cerebrovascular disease

Background:

  • The brain's high energy demand necessitates a continuous nutrient supply.
  • Brain attacks (stroke) cause severe nutrient deprivation, impacting brain structure and function.
  • The brain is uniquely vulnerable to nutrient restriction and starvation due to its metabolic profile.

Purpose of the Study:

  • To highlight the critical role of nutrient supply in brain function and recovery after stroke.
  • To underscore the metabolic vulnerabilities of the brain during ischemic events.
  • To identify the need for novel interventions addressing nutrient consumption and metabolic lesions post-stroke.

Main Methods:

  • Review of existing literature on brain metabolism and stroke pathophysiology.

Related Experiment Videos

  • Analysis of the impact of nutrient deprivation on brain structure and function.
  • Examination of metabolic changes during ischemia and reperfusion.

    • Main Results:

    • Brain's complete dependence on uninterrupted nutrient supply for energy production and function.
    • Stroke leads to devastating structural and functional deficits due to blood flow and nutrient loss.
    • Ischemia induces changes compromising nutrient consumption, even after blood flow restoration.
    • The brain's metabolic characteristics increase susceptibility to starvation-induced damage.

    Conclusions:

    • Restoring nutrient consumption is crucial for improving outcomes after stroke.
    • Novel therapeutic strategies are needed to counteract metabolic damage from stroke and reperfusion injury.
    • Addressing the brain's high energetic demands and metabolic lesions is key to mitigating stroke's impact.