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Stimulation of NF-kappa B activation and gene expression by platelet-activating factor
R D Ye1, V V Kravchenko, Z Pan
1Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
Advances in Experimental Medicine and Biology
|January 1, 1996
Abstract:
PAF stimulation of NF-kappa B activation and transcription of immediate-early genes have been investigated in peripheral blood mononuclear cells and in transfected Chinese hamster ovary cells expressing the cloned PAF receptor. These studies identified a G protein-coupled pathway for PAF induction of gene expression and transcription factor activation, which differs from the mechanisms employed by other immediate-early gene inducers. Potential significance of PAF induced NF-kappa B activation is discussed.