Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does hormone replacement therapy inhibit coronary artery calcification?

J Shemesh1, Y Frenkel, L Leibovitch

  • 1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.

Obstetrics and Gynecology
|June 1, 1997
PubMed
Summary

Postmenopausal women using hormone replacement therapy (HRT) showed significantly less coronary calcium. This suggests HRT may reduce coronary calcification prevalence in women without prior heart disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Room temperature "optical nanodiamond hyperpolarizer": Physics, design, and operation.

The Review of scientific instruments·2020
Same author

Hyperpolarized relaxometry based nuclear T<sub>1</sub> noise spectroscopy in diamond.

Nature communications·2019
Same author

Wide dynamic range magnetic field cycler: Harnessing quantum control at low and high fields.

The Review of scientific instruments·2019
Same author

Enhanced dynamic nuclear polarization via swept microwave frequency combs.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

No increased death toll for long-term menopausal hormone therapy.

Climacteric : the journal of the International Menopause Society·2017
Same author

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.

Climacteric : the journal of the International Menopause Society·2017

Area of Science:

  • Cardiology
  • Endocrinology
  • Radiology

Background:

  • Coronary artery disease is a leading cause of mortality in postmenopausal women.
  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
  • The impact of HRT on early coronary artery disease markers is not fully understood.

Purpose of the Study:

  • To investigate the association between HRT use and coronary artery calcification.
  • To evaluate coronary calcium prevalence in postmenopausal women with and without HRT history.
  • To assess HRT's role in early coronary artery disease development.

Main Methods:

  • Computed tomography (CT) was used to assess coronary calcium.
  • Compared 41 postmenopausal HRT users with 37 age-matched non-HRT controls.

Related Experiment Videos

  • Analyzed prevalence and extent of coronary calcification.

    • Main Results:

    • Coronary calcification was found in 28.2% of all women studied.
    • HRT users had significantly lower coronary calcium prevalence (14.6%) versus non-users (43.2%).
    • HRT use was the sole significant predictor of reduced coronary calcification.

    Conclusions:

    • HRT use is associated with a decreased prevalence of coronary calcification.
    • Findings suggest a potential cardioprotective effect of HRT regarding coronary atherosclerosis.
    • Further research is warranted to confirm HRT's role in cardiovascular disease prevention.