Interdependence of the endocrine and immune systems

The cross-talk involving the endocrine and immune systems is now largely established. These systems actually use similar ligands and receptors to establish a physiological intra- and inter-system communication circuitry, which apparently plays a relevant role in homeostasis (reviewed in Blalock, 1992). Accordingly, classical hormones such as prolactin (PRL), growth hormone (GH) and even glucocorticoids (GC) can be produced by cells of the immune system, whereas a variety of cytokines, originally described as being produced by cells of the immune system, are synthesized and released by a variety of endocrine glands and nervous tissue. Moreover, specific receptors for such distinct molecular families can be detected in both the immune and endocrine systems.