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How to express an effect mean as percentage of a control mean?
T J Feuerstein1, R Rossner, M Schumacher
1Sektion Klinische Neuropharmakologie der Neurologischen Universitätsklinik, Neurozentrum, Freiburg, Germany.
Journal of Pharmacological and Toxicological Methods
|June 1, 1997
Abstract:
The expression of effects as % of corresponding controls requires to consider the variance of these controls. Fieller's Theorem allows the appropriate calculation of the deviation of % values. The Zero-Method, which wrongly assumes that the variance of controls is zero, may lead to doubtful interpretations, as shown with experimental examples on the inhibition of depolarization-evoked transmitter release.