Search research articles

Search research articles

Related Experiment Videos

How Salmonella became a pathogen

E A Groisman¹, H Ochman

¹Dept of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110-1093, USA. groisman@borcim.wustl.edu

Trends in Microbiology

|September 19, 1997

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Selection on the genic location of disruptive elements.

Trends in genetics : TIG·2007

Same author

A Mg2+-responding RNA that controls the expression of a Mg2+ transporter.

Cold Spring Harbor symposia on quantitative biology·2007

Same author

Gene decay in archaea.

Archaea (Vancouver, B.C.)·2007

Same author

Type III secretion system genes in clinical Aeromonas isolates.

Journal of clinical microbiology·2004

Same author

Population genetics and population biology: what did they bring to the epidemiology of transmissible diseases? An e-debate.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2003

Same author

Pathogenicity islands of Shigella.

Current topics in microbiology and immunology·2002

Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026

Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026

Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026

Same journal

Cronobacter spp.

Trends in microbiology·2026

Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026

Same journal

Critical role of the inflammatory rheostat in influenza-associated pulmonary aspergillosis.

Trends in microbiology·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Salmonella virulence relies on numerous genes across its genome, unlike other pathogens. The acquisition of pathogenicity islands has been key to Salmonella's evolution and its ability to cause disease.

Area of Science:

Microbiology
Genomics
Evolutionary Biology

Background:

Pathogen virulence is often linked to specific genomic regions.
The facultative intracellular lifestyle of Salmonella requires a broad gene set.
Salmonella's genome is characterized by the presence of pathogenicity islands.

Purpose of the Study:

To highlight the genomic basis of Salmonella virulence.
To contrast Salmonella's virulence strategy with other pathogens.
To emphasize the role of pathogenicity islands in Salmonella evolution.

Main Methods:

Comparative genomics analysis.
Review of existing literature on Salmonella pathogenicity.
Analysis of gene distribution in the Salmonella chromosome.

Related Experiment Videos

Main Results:

Salmonella's virulence depends on a large, chromosomally distributed gene set.
Pathogenicity islands are crucial for Salmonella's unique virulence traits.
This contrasts with pathogens where virulence is often confined to single genomic regions.

Conclusions:

The evolution of Salmonella involved the acquisition of multiple pathogenicity islands.
These islands contribute significantly to the microorganism's virulence.
Salmonella's genomic structure is adapted for its facultative intracellular lifestyle.