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Primary cutaneous lymphomas: a study of 37 cases
P Andrès1, M L Lepagney, B Bureau
1Department of Dermatology, Hôtel-Dieu Hospital, Nantes, France.
International Journal of Dermatology
|August 1, 1997
Summary
Primary cutaneous lymphomas (PCL) in B and T phenotypes showed similar clinical features and good prognosis, with high remission rates after nonaggressive treatment. Frequent relapses highlight the need for adjuvant therapy, especially in disseminated cases.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Retrospective study of 37 isolated primary cutaneous lymphoma (PCL) cases (22 B-cell, 15 T-cell).
- Excluded patients with epidermotrophic infiltrate (mycosis fungoides, Sézary syndrome).
Purpose of the Study:
- To analyze clinical, histologic, and immunohistochemical features of PCL.
- To compare B-cell and T-cell PCL phenotypes.
- To evaluate prognosis and treatment response based on the Willemze classification.
Main Methods:
- Selection of PCL cases with isolated cutaneous involvement (>6 months) and negative spread studies.
- Inclusion of both localized and disseminated lesions.
- Histologic confirmation and immunohistochemical analysis.
Main Results:
- Similar clinical features, therapeutic response, course, and prognosis between B and T phenotype PCL.
- Typical lesion: erythematous nodule, often localized.
- High sensitivity to nonaggressive treatment, achieving complete or partial remission in all cases.
Conclusions:
- Good overall prognosis for PCL, including disseminated forms (48-month survival: 78% T-cell, 89% B-cell).
- Frequent cutaneous relapses observed, particularly in disseminated disease, necessitating adjuvant treatment considerations.
- Extracutaneous involvement is rare but indicates a poor prognosis.