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1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in

W M Brooks1, M H Wesley, P W Kodituwakku

  • 1Center for Non-Invasive Diagnosis, University of New Mexico, Albuquerque 87131, USA. brooks@lizard.unm.edu

Stroke
|October 28, 1997
PubMed
Abstract

Insights

Proton magnetic resonance spectroscopy (MRS) can differentiate white matter hyperintensities (WMH) in subcortical arteriosclerotic encephalopathy (SAE) patients from those in normal elderly individuals. This technique suggests distinct underlying causes for these brain changes.

Area of Science:

  • Neurology
  • Radiology
  • Biochemistry

Background:

  • White matter hyperintensities (WMH) on brain MRI are common in the elderly.
  • Radiologically, WMH in normal aging can resemble those seen in subcortical arteriosclerotic encephalopathy (SAE).

Purpose of the Study:

  • To differentiate WMH in SAE patients from similar changes in normal elderly individuals using MRI.
  • Investigate the biochemical differences in WMH between symptomatic SAE patients and asymptomatic elderly subjects.

Main Methods:

  • Studied three groups: symptomatic SAE patients with WMH, asymptomatic subjects with WMH, and normal elderly controls.
  • Utilized proton magnetic resonance spectroscopy (1H-MRS) to analyze metabolite concentrations (NAA, Cre, Cho) within WMH.
  • Calculated metabolite ratios (NAA/Cre, NAA/Cho) to assess biochemical differences.

Main Results:

  • Reduced NAA/Cre and NAA/Cho ratios were observed in the SAE group compared to asymptomatic groups (P < .05).
  • NAA levels were decreased and Cho levels elevated in SAE patients versus controls (P < .05).
  • WMH volumes were similar in SAE and asymptomatic WMH groups, and significantly larger than in normal controls.

Conclusions:

  • Proton MRS effectively distinguishes WMH in SAE patients from those in asymptomatic elderly individuals.
  • The findings suggest differing etiologies for white matter hyperintensities in these distinct patient groups.

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