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Surgical Models of Gastroesophageal Reflux with Mice
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Surgical treatment of gastroesophageal reflux disease

S Horgan1, C A Pellegrini

  • 1Department of Surgery, University of Washington School of Medicine, Seattle, USA.

The Surgical Clinics of North America
|November 5, 1997
PubMed

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Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...