Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pancreas01:19

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fertility drugs and breast and ovarian cancer.

Lancet (London, England)·1995
Same author

Cancer mortality in Europe, 1990-92.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·1995
Same author

[Trends in skin cancers in the Vaud canton, 1976-1992].

Revue medicale de la Suisse romande·1995
Same author

Trends of skin cancer in the Canton of Vaud, 1976-92.

British journal of cancer·1995
Same author

Pancreatitis and the risk of pancreatic cancer.

Pancreas·1995
Same author

Mortality from benign prostatic hyperplasia: worldwide trends 1950-92.

Journal of epidemiology and community health·1995
Same journal

External quality assessment programs in cytogenomics in the Lombardy Region, Italy (2018-2024): performance and trends.

Annali dell'Istituto superiore di sanita·2026
Same journal

Spontaneous orienting of untrained companion dogs naïve to human epilepsy toward odor samples from an unfamiliar human in a controlled non-social paradigm: a proof-of-concept.

Annali dell'Istituto superiore di sanita·2026
Same journal

Addressing food and nutrition insecurity in European countries: a scoping review of strategies and policies.

Annali dell'Istituto superiore di sanita·2026
Same journal

Women's experiences of membrane sweeping for labour induction: a phenomenological qualitative study.

Annali dell'Istituto superiore di sanita·2026
Same journal

Evaluating the usefulness of the Mediterranean Diet Quality Index (KIDMED) in assessing eating habits and nutritional status among preschool children.

Annali dell'Istituto superiore di sanita·2026
Same journal

Optimizing sample preparation for homogeneous mycotoxin distribution in official control analyses.

Annali dell'Istituto superiore di sanita·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
07:08

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

[Pancreas carcinoma]

C La Vecchia1

  • 1Istituto di Statistica Medica e Biometria, Università degli Studi, Milano.

Annali Dell'Istituto Superiore Di Sanita
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Pancreatic cancer mortality is rising in Italy, linked to increased tobacco smoking and better diagnosis. Other factors include pancreatitis and diet, but coffee and alcohol show no clear link.

More Related Videos

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma
03:55

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma

Published on: December 29, 2023

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Related Experiment Videos

Last Updated: May 26, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
07:08

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma
03:55

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma

Published on: December 29, 2023

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Area of Science:

  • Oncology
  • Epidemiology

Context:

  • Pancreatic cancer mortality shows an increasing trend in Italy.
  • Italian rates remain relatively low on a European scale.
  • This rise is observed in both men and women.

Purpose:

  • To analyze trends and risk factors associated with pancreatic cancer in Italy.
  • To investigate the role of tobacco smoking, pancreatitis, diabetes, diet, coffee, and alcohol consumption.

Summary:

  • Increased pancreatic cancer mortality in Italy is partly attributed to improved diagnosis and higher tobacco smoking exposure.
  • Pancreatitis is a known risk factor, while diabetes association is strongest shortly before diagnosis.
  • Dietary factors like high fat and low fruit/vegetable intake may increase risk, but remain poorly understood. Coffee and alcohol show no consistent association.

Impact:

  • Highlights the significant impact of tobacco smoking on pancreatic cancer trends.
  • Underscores the need for further research into dietary correlates of pancreatic cancer.
  • Provides epidemiological insights into pancreatic cancer in the Italian population.