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Four-stranded DNA formed by isoguanine quartets: complex stoichiometry, thermal stability and resistance against
1Laboratorium für Organische und Bioorganische Chemie, Universität Osnabrück, Germany.
Abstract:
Single stranded DNA-fragments containing short runs of isoguanine such as d(T4iG4T4) (5) or d(iG4T4) (6) form quartet structures by self-assembly of the isoguanine residues. The stoichiometry of the complexes is deduced from mixed aggregates formed between d(T4iG4T4) and d(iG4T4). The iGd-tetrads are more stable with regard to their thermal denaturation and to their resistance against enzymatic phosphodiester hydrolysis than those formed by dG.