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Sepsis at a neonatal intensive care unit: a four-year retrospective study (1989-1992)
E Leibovitz1, O Flidel-Rimon, A Juster-Reicher
1Department of Neonatology, Kaplan Hospital, Rehovot, Israel.
Israel Journal of Medical Sciences
|January 22, 1998
Summary
Neonatal sepsis trends show early-onset Streptococcus agalactiae followed by Klebsiella spp. and Candida spp. in late-onset infections, with significant mortality rates.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Neonatal sepsis is a major cause of mortality in newborns.
- Understanding pathogen trends and resistance is crucial for effective treatment.
Purpose of the Study:
- To analyze trends in neonatal sepsis pathogens and outcomes.
- To identify changes in causative agents and antibiotic resistance patterns.
Main Methods:
- Retrospective analysis of neonatal intensive care unit admissions.
- Identification of pathogens causing early- and late-onset sepsis.
- Assessment of mortality rates and antibiotic resistance.
Main Results:
- Streptococcus agalactiae and E. coli were primary early-onset sepsis pathogens, with S. agalactiae incidence decreasing later.
- Klebsiella spp., coagulase-negative staphylococci, and Candida spp. were dominant in late-onset sepsis.
- High mortality was observed, particularly with S. agalactiae and Klebsiella spp. infections, alongside emerging multi-antibiotic resistance.
Conclusions:
- Significant shifts in neonatal sepsis etiology were observed.
- Emergence of virulent, antibiotic-resistant Klebsiella spp. poses a serious threat.
- Persistent high incidence of Candida sepsis requires attention.