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Related Experiment Videos

Is liquid ventilation a reasonable alternative?

J S Greenspan1, G M Cleary, M R Wolfson

  • 1Department of Neonatology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, USA.

Clinics in Perinatology
|April 2, 1998
PubMed
Summary
This summary is machine-generated.

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Liquid breathing, using perfluorochemicals, offers potential for improved gas exchange in critically ill neonates. Further research is needed to clarify factors before routine clinical use.

Area of Science:

  • Neonatal medicine
  • Respiratory physiology
  • Liquid ventilation

Background:

  • Liquid breathing has been explored for nearly 80 years.
  • Proposed for improving gas exchange in critically ill infants since the 1970s.
  • Extensive laboratory work with perfluorochemicals preceded clinical trials.

Purpose of the Study:

  • To discuss the process of liquid breathing in neonates.
  • To review the physiologic response to liquid breathing in neonates.
  • To identify factors needing clarification for routine clinical therapy approval.

Main Methods:

  • Review of existing literature on liquid breathing.
  • Discussion of perfluorochemical liquid ventilation processes.
  • Analysis of physiologic responses in neonatal subjects.

Related Experiment Videos

Main Results:

  • Liquid breathing has a long history in medical literature.
  • Clinical trials have been conducted in infants, children, and adults.
  • The article details the process and physiological responses in neonates.

Conclusions:

  • Liquid breathing shows promise for neonatal respiratory support.
  • Further clarification of specific factors is required.
  • Approval as a routine clinical therapy is pending further investigation.