[The histone hydrolase of the liver and kidneys in rats in postnatal ontogeny]

It has been demonstrated that total homogenates and subcellular fractions of the liver and kidneys of rats exhibit proteolytic activity which specifically digests histone at pH 8.5. The activity of histone hydrolase undergoes age changes in all the subcellular fractions of the liver and kidneys, except the nuclear fraction. Various histone fractions possess different sensitivity to the effect of histone hydrolase. The described enzyme from the liver and kidneys of rats is similar to the histone protease of other vertebrates, although in some respects its properties are somewhat different.