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Related Experiment Videos

A quantitative method for fast diffusion imaging using magnetization-prepared TurboFLASH

D L Thomas1, G S Pell, M F Lythgoe

  • 1Royal College of Surgeons Unit of Biophysics, Institute of Child Health, University College London Medical School, UK.

Magnetic Resonance in Medicine
|June 11, 1998
PubMed
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This study introduces a modified TurboFLASH sequence to accurately measure apparent diffusion coefficient (ADC) in vivo. The improved method corrects for eddy current-induced errors, enabling faster and more reliable diffusion imaging.

Area of Science:

  • Magnetic Resonance Imaging
  • Diffusion Tensor Imaging
  • Biomedical Engineering

Background:

  • Accelerating in vivo apparent diffusion coefficient (ADC) measurements is crucial for reducing scan times.
  • Existing TurboFLASH sequences with driven equilibrium Fourier transform (DEFT) pulse combinations are susceptible to eddy current-induced artifacts, compromising ADC accuracy.
  • These artifacts lead to incomplete magnetization refocusing during diffusion preparation.

Purpose of the Study:

  • To develop a modified TurboFLASH sequence for accurate and rapid in vivo ADC measurement.
  • To address and eliminate errors caused by eddy current-induced magnetic field inhomogeneities.
  • To investigate the impact of reduced inter-acquisition delay times on measurement accuracy.

Main Methods:

Related Experiment Videos

  • A modified TurboFLASH sequence incorporating phase-cycling of the second 90-degree pulse was developed to correct for eddy current effects.
  • The sequence's performance was validated using an agar phantom and in vivo rat brain imaging at 8.5 T.
  • The effect of reducing the delay time between acquisitions on measurement accuracy was systematically evaluated.

    • Main Results:

    • The modified TurboFLASH sequence successfully eliminated eddy current-induced artifacts, leading to accurate ADC values.
    • Experimental validation on phantom and in vivo rat brain demonstrated the sequence's effectiveness.
    • A reduction in inter-experiment delay time was found to be feasible within certain limits without sacrificing measurement accuracy.

    Conclusions:

    • The proposed phase-cycling modification to the TurboFLASH sequence effectively corrects for eddy current-induced errors in ADC measurements.
    • This optimized sequence allows for faster in vivo diffusion imaging without compromising accuracy.
    • The findings support the use of this modified sequence for more efficient diffusion MRI studies.