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[Cross susceptibility of ototoxicity about aminoglycoside antibiotics]

J Wu1

  • 1Military General Hospital, Jinan.

Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|January 1, 1997
PubMed

Insights

Aminoglycoside (AMI) antibiotics can cause deafness, especially in children with a family history. Genetic factors, particularly maternal inheritance, increase susceptibility to AMI toxicity.

Area of Science:

  • Pharmacogenetics
  • Ototoxicity
  • Genetic Epidemiology

Context:

  • Aminoglycoside antibiotics are widely used but can cause hearing loss.
  • Familial aggregation of aminoglycoside-induced deafness suggests a genetic component.
  • Previous studies have indicated potential genetic predispositions to aminoglycoside ototoxicity.

Purpose:

  • To investigate the genetic basis of aminoglycoside-induced deafness in three families.
  • To determine the inheritance pattern of susceptibility to aminoglycoside toxicity.
  • To identify specific aminoglycoside antibiotics exhibiting cross-susceptibility.

Summary:

  • Familial investigation revealed cross-susceptibility among certain aminoglycoside antibiotics.
  • Individuals with a family history of aminoglycoside-induced deafness showed increased susceptibility to toxicity, even at low doses.
  • This susceptibility is primarily inherited maternally and influenced by general chromosomes.
  • Children with a family history are particularly vulnerable to aminoglycoside toxicity.

Impact:

  • Highlights the importance of inquiring about family medical history before prescribing aminoglycosides.
  • Suggests prohibiting aminoglycoside use in patients with a history of maternal inheritance of deafness.
  • Informs clinical practice and genetic counseling regarding aminoglycoside safety.

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