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[Malignant changes in laryngeal papilloma with 13 case reports]
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|February 1, 1997
Summary
Malignant changes occurred in 30.2% of laryngeal papilloma cases. Early detection and combined surgical and radiation treatment are crucial for managing this condition.
Area of Science:
- Otolaryngology
- Oncology
- Pathology
Context:
- Laryngeal papilloma is a laryngeal neoplasm.
- Malignant transformation of laryngeal papilloma is a known complication.
- Epithelial atypia in laryngeal papilloma indicates early-stage carcinoma.
Purpose:
- To report on the incidence of malignant changes in laryngeal papilloma.
- To discuss the pathogenesis and diagnosis of malignant transformation.
- To recommend optimal treatment strategies for malignant laryngeal papilloma.
Summary:
- A study of 43 laryngeal papilloma cases revealed 13 instances of malignant change, a rate of 30.2%.
- Laryngeal papilloma with epithelial atypia signifies the onset of carcinoma, necessitating prompt and aggressive management.
- Effective treatment involves surgical resection with a minimum 0.5 cm safe margin, followed by adjuvant radiation therapy; radiation alone proved ineffective.
Impact:
- Highlights the significant risk of malignant transformation in laryngeal papilloma.
- Emphasizes the importance of vigilant monitoring and early intervention for laryngeal papilloma.
- Provides evidence-based recommendations for the surgical and oncological management of malignant laryngeal papilloma.