Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hyaluronidase in meningococcus]

T K Mironova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Most meningococcus strains contain hyaluronidase, an enzyme crucial for cerebrospinal fluid invasion. This enzyme was more prevalent in invasive strains and serogroup A, but not linked to mouse virulence.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Meningococcal plasmids].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1989
    Same author

    [Adhesion in meningococcus].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1989
    Same author

    [Interaction of Neisseria meningitidis with eukaryotic cells in a mixed infection in vitro].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1988
    Same author

    [Preventive and therapeutic action of sera to the Re mutant of Salmonella minnesota in experimental generalized meningococcal infection].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1988
    Same author

    [A common meningococcaL intergroup antigen: immunological and immunochemical study].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1987
    Same author

    [Epidemiological significance of carriers of hyaluronidase-active meningococci].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·1986
    Same journal

    [MICROBIOCENOSIS, IMMUNE SYSTEM AND HEREDITY].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    Same journal

    [USE OF VIBRIO CHOLERAE SURFACE STRUCTURES FOR SPECIFIC PROPHY- LAXIS AND DIAGNOSTICS OF CHOLERA].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    Same journal

    [EVALUATION OF NUTRIENT MEDIA TO GROW SOME INFECTION DISEASES CAUSATIVE AGENTS].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    Same journal

    [ASSESSMENT OF ATTITUDES TOWARDS IMMUNIZATION IN DIFFERENT GROUPS OF POPULATION OF THE RUSSIAN FEDERATION].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    Same journal

    [COMPARATIVE CHARACTERISTICS OF IMMUNE STATUS OF PATIENTS WITH CHRONIC FORMS OF VIRAL HEPATITIS B, C, D AND HEALTHY INDIVIDUALS].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    Same journal

    [FREQUENCY OF OCCURRENCE OF POLYMORPHIC VARIANTS OF IL28B GENE AND GENOTYPES OF HEPATITIS C VIRUS IN POPULATION OF YAKUTIA: CLINICAL OUTCOMES].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2019
    See all related articles

    Area of Science:

    • Microbiology
    • Enzymology
    • Pathogenesis

    Background:

    • Neisseria meningitidis (meningococcus) is a significant human pathogen.
    • Hyaluronidase is an enzyme implicated in bacterial invasion and spread.
    • Understanding meningococcal enzyme production is key to deciphering pathogenesis.

    Purpose of the Study:

    • To investigate the prevalence of hyaluronidase in meningococcus strains.
    • To correlate hyaluronidase production with strain characteristics and invasiveness.
    • To assess the relationship between hyaluronidase and virulence in a murine model.

    Main Methods:

    • Testing of 204 meningococcus isolates for hyaluronidase presence.
    • Categorization of strains based on origin (cerebrospinal fluid vs. nasopharyngeal mucosa).

    Related Experiment Videos

  • Serogrouping of isolates and virulence assessment in mice.

    • Main Results:

    • Hyaluronidase was detected in 45.5% of all tested meningococcus strains.
    • Significantly higher prevalence (83%) in strains isolated from cerebrospinal fluid compared to nasopharyngeal strains (25.5%).
    • Hyaluronidase was most common in serogroup A strains (higher than other groups).

    Conclusions:

    • Hyaluronidase production is associated with meningococcal invasiveness, particularly in strains reaching the cerebrospinal fluid.
    • Serogroup A meningococci exhibit a higher capacity for hyaluronidase production.
    • Hyaluronidase production in vitro does not correlate with virulence in a mouse model of infection.