Enalapril microbial biosensor
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Updated: Oct 28, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
S Fleschin1, C Bala, A A Bunaciu
1Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Romania.
Abstract:
Enalapril maleate (EMa) belongs to a new class of antihypertensive agents known as angiotensin converting enzyme (ACE) inhibitors. This paper describes the development of a microbial biosensor for EMa using induced Bacillus subitilis cells. This biosensor measures the acceleration of respiration during specific metabolic pathways of this drug. It has been applied, with good results, for determination of the active ingredient in the pharmaceutical tablet formulations.
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