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Enalapril microbial biosensor

S Fleschin1, C Bala, A A Bunaciu

  • 1Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Romania.

Preparative Biochemistry & Biotechnology
|August 26, 1998
PubMed
Summary
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A new microbial biosensor was developed using Bacillus subtilis to detect enalapril maleate, an ACE inhibitor. This biosensor accurately measures the drug

Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Microbiology

Background:

  • Enalapril maleate (EMa) is a key antihypertensive drug belonging to the angiotensin-converting enzyme (ACE) inhibitor class.
  • Accurate quantification of EMa is crucial for pharmaceutical quality control and therapeutic efficacy.

Purpose of the Study:

  • To develop and validate a novel microbial biosensor for the detection and quantification of enalapril maleate.
  • To utilize induced Bacillus subtilis cells for a sensitive and specific EMa measurement.

Main Methods:

  • Development of a microbial biosensor employing induced Bacillus subtilis.
  • Measurement of the drug's effect on the respiration rate of the microbial cells.
  • Application of the biosensor for the determination of EMa in pharmaceutical formulations.

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Main Results:

  • Successful development of a microbial biosensor for enalapril maleate.
  • The biosensor effectively measures the acceleration of respiration linked to EMa metabolism.
  • Good results were obtained when applied to determine the active ingredient in pharmaceutical tablets.

Conclusions:

  • A Bacillus subtilis-based microbial biosensor offers a viable method for enalapril maleate determination.
  • This biosensor provides a sensitive and efficient approach for quality control of enalapril maleate in pharmaceutical products.