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[Topical photodynamic therapy in dermatology]
M Grob1, P Schmid-Grendelmeier
1Dermatologisches Ambulatorium des Stadtspitals Triemli, Zürich.
Therapeutische Umschau. Revue Therapeutique
|October 3, 1998
Summary
Topical photodynamic therapy (TPDT) using 5-Aminolevulinic acid (ALA) offers a noninvasive treatment for skin tumors and conditions like psoriasis. This method minimizes side effects compared to systemic administration, providing excellent cosmetic outcomes.
Area of Science:
- Oncology
- Dermatology
- Photochemistry
Context:
- Photodynamic therapy (PDT) is an experimental, noninvasive treatment for malignant tumors.
- Systemic photosensitizer administration causes skin photosensitivity.
- Topical application of photosensitizers is a novel approach.
Purpose:
- To investigate the efficacy and tolerability of topical photodynamic therapy (TPDT) using 5-Aminolevulinic acid (ALA).
- To explore ALA-TPDT for treating precancerous and cancerous epithelial skin tumors.
- To assess ALA-TPDT for non-tumoral applications, such as psoriasis.
Summary:
- 5-Aminolevulinic acid (ALA) is a photosensitizer precursor to endogenous porphyrins.
- ALA-TPDT involves topical application of ALA followed by light exposure.
- This method selectively destroys neoplastic cells and exhibits good patient tolerance.
Impact:
- ALA-TPDT is successfully used for actinic keratoses, basal-cell carcinoma, squamous-cell carcinoma, and Bowen disease.
- It provides an alternative treatment for superficial skin tumors.
- Excellent cosmetic results and patient tolerability are key benefits.