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[Nephritic colic due to indinavir]

J F Hermieu1, M H Prévot, V Ravery

  • 1Clinique Urologique, Hôpital Bichat, Paris.

Presse Medicale (Paris, France : 1983)
|October 13, 1998
PubMed
Summary
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Urinary lithiasis is a frequent complication of indinavir therapy, occurring in 9% of patients. Management includes hydration and urine acidification, but avoid nonsteroidal anti-inflammatory drugs due to renal toxicity risks.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Context:

  • Indinavir, an HIV protease inhibitor, is associated with a significant risk of urinary lithiasis.
  • Urinary tract stones are a known, yet serious, adverse effect impacting patient management.
  • Understanding the frequency and management of these stones is crucial for HIV treatment protocols.

Purpose:

  • To evaluate the frequency of urinary lithiasis in patients treated with indinavir.
  • To assess curative and preventive measures for indinavir-induced urinary stones.
  • To analyze the clinical presentation, radiological findings, and laboratory results associated with these stones.

Summary:

  • Urinary lithiasis occurred in 9% of patients treated with indinavir.
  • The stones were primarily composed of indinavir monohydrate.

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  • Management strategies included hyperhydration and urine acidification; emergency drainage was required in 3% of cases.
  • Nonsteroidal anti-inflammatory drugs demonstrated renal toxicity and should be avoided.

    • Impact:

    • Highlights the importance of monitoring for urinary lithiasis in patients on indinavir.
    • Provides evidence-based recommendations for managing indinavir-induced nephrolithiasis.
    • Informs clinical practice regarding the avoidance of specific medications (NSAIDs) and the need for risk assessment in patients receiving indinavir.