Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fat metabolism in exercise

R R Wolfe1

  • 1University of Texas Medical Branch Galveston, Shriners Burns Institute Metabolism Unit 77550, USA.

Advances in Experimental Medicine and Biology
|October 22, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The anabolic response to resistance exercise and a protein-rich meal is not diminished by age.

The journal of nutrition, health & aging·2011
Same author

Social problems of the hospitalized elderly.

Canadian family physician Medecin de famille canadien·2010
Same author

The danger of weight loss in the elderly.

The journal of nutrition, health & aging·2008
Same author

The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation.

American journal of physiology. Cell physiology·2007
Same author

Management strategy for very mild aortic valve stenosis.

Pediatric cardiology·2006
Same author

Amino acid supplementation alters bone metabolism during simulated weightlessness.

Journal of applied physiology (Bethesda, Md. : 1985)·2005
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Fatty acid oxidation during exercise is controlled by both availability and muscle

Area of Science:

  • Exercise Physiology
  • Metabolic Regulation
  • Skeletal Muscle Metabolism

Background:

  • Fatty acids are a primary energy source mobilized from adipose tissue and muscle.
  • Exercise intensity influences the availability and utilization of fatty acids for energy.
  • Understanding control mechanisms of fatty acid oxidation is crucial for optimizing exercise performance and metabolism.

Purpose of the Study:

  • To differentiate the roles of fatty acid availability versus muscle's oxidative capacity in regulating fat oxidation during exercise.
  • To investigate the impact of exercise intensity on lipolysis and fatty acid oxidation.
  • To identify the primary site of control for fatty acid oxidation within skeletal muscle.

Main Methods:

  • Experimental manipulation of plasma free fatty acid (FFA) levels via lipid infusion during exercise.

Related Experiment Videos

  • Measurement of fatty acid oxidation rates at varying exercise intensities (e.g., 65% and 85% of VO2 max).
  • Assessment of muscle's capacity for fatty acid oxidation, focusing on mitochondrial transport.

    • Main Results:

    • Fatty acid oxidation increases with availability, as shown by enhanced oxidation during lipid infusion at high intensity.
    • Muscle's capacity to oxidize fatty acids is limited, particularly at high exercise intensities.
    • Mitochondrial transport of fatty acids into muscle cells is identified as a key regulatory step.

    Conclusions:

    • Fatty acid availability is a determinant, but not the sole factor, controlling fat oxidation during exercise.
    • Skeletal muscle's intrinsic mechanisms, specifically substrate competition with glycolysis, limit fatty acid oxidation at high intensities.
    • Glycolysis, driven by muscle glycogen, inhibits fatty acid oxidation by restricting mitochondrial fatty acid uptake during intense exercise.