Related Experiment Videos
Approaches to population kinetic analysis with application to metabolic studies
P Vicini1, P H Barrett, C Cobelli
1Department of Bioengineering, University of Washington, Seattle, USA.
Advances in Experimental Medicine and Biology
|October 22, 1998
Summary
Population kinetic analysis quantifies inter-subject variability in pharmacokinetic studies using longitudinal data. This work reviews parametric methods for nonlinear mixed effects models and available software for analysis.
Area of Science:
- Pharmacokinetics
- Statistical Modeling
- Metabolism
Background:
- Population kinetic analysis is a standard method for quantifying inter-subject variability in pharmacokinetics.
- Also known as analysis of repeated measurement or longitudinal data in statistics.
Purpose of the Study:
- To present the population kinetics problem and its historical significance.
- To describe and apply parametric methods for nonlinear mixed effects models to case studies in intermediary metabolism.
- To review available software for population kinetic analysis.
Main Methods:
- Description and application of two-stage parametric methods for nonlinear mixed effects models.
- Utilizing case studies in intermediary metabolism.
Main Results:
- Demonstration of various parametric methods applied to intermediary metabolism case studies.
- Overview of software tools for population kinetic analysis.
Conclusions:
- Population kinetic analysis is crucial for understanding inter-subject variability.
- Parametric methods for nonlinear mixed effects models are applicable to metabolic studies.
- Software availability aids in conducting population kinetic analyses.