Chemical genetics resulting from a passion for synthetic organic chemistry

BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.

Nucleic acids research·2014

Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.

Cancer research·2014

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.

Cell death & disease·2013

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.

Organic letters·2002

A one-bead, one-stock solution approach to chemical genetics: part 2.

Chemistry & biology·2002

A one-bead, one-stock solution approach to chemical genetics: part 1.

Chemistry & biology·2002

Structural optimization of 2-(2-aminopyridin-4-yl)-N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as potent interleukin-1 receptor-associated kinase 4 inhibitors.

Bioorganic & medicinal chemistry·2026

Discovery of SARS-CoV-2 PLpro covalent inhibitors enabled by a novel reversible covalent chloroalkyne warhead.

Bioorganic & medicinal chemistry·2026

Functional mapping of the Trypanosoma cruzi serinome by fluorophosphonate activity-based protein profiling.

Bioorganic & medicinal chemistry·2026

Design, synthesis and evaluation of fluorinated CYP1B1 inhibitors based on a trans-stilbene scaffold.

Bioorganic & medicinal chemistry·2026

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

Bioorganic & medicinal chemistry·2026

A novel ring-opened ebselen scaffold with potent anti-angiogenic activity against cancer: synthesis, biological evaluation, and molecular docking.

Bioorganic & medicinal chemistry·2026

SaBox/Cu(II)-catalyzed enantioselective Claisen rearrangement of 2-allyloxycyclohex-2-en-1-ones and 3-allyloxy-4H-chromenones.

Organic & biomolecular chemistry·2026

Selective synthesis of phenylpropanoid carbonyl and diphenylalkyl derivatives via para-alkylation of tertiary anilines with cyclopropanol.

Chemical communications (Cambridge, England)·2026

Single-Atom Ru on N-Heterocyclic Carbene-Functionalized Hypercrosslinked Polymers for N-Formylation of Amines with CO2 and H2.

Molecules (Basel, Switzerland)·2026

Potential-regulated CO migration and CC bond formation on a co single-atom/Fe3 cluster tandem catalyst for CO2 electroreduction.

Journal of colloid and interface science·2026

Selective Chlorination of Toluene and Halobenzenes Using Modified BaSO4-Supported Catalysts: A Sustainable Approach with (NH4)2S2O8 and H2O2 as Oxidants.

Nanomaterials (Basel, Switzerland)·2026

Palladium-Catalyzed Self- and Cross-Dimerization Annulation of β-CF3-1,3-Enynamides: An Access to Functionalized Bicyclo[4.2.0]trienes.

Organic letters·2026

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Chemical genetics resulting from a passion for synthetic organic chemistry

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BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.

Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.

A one-bead, one-stock solution approach to chemical genetics: part 2.

A one-bead, one-stock solution approach to chemical genetics: part 1.

Structural optimization of 2-(2-aminopyridin-4-yl)-N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as potent interleukin-1 receptor-associated kinase 4 inhibitors.

Discovery of SARS-CoV-2 PLpro covalent inhibitors enabled by a novel reversible covalent chloroalkyne warhead.

Functional mapping of the Trypanosoma cruzi serinome by fluorophosphonate activity-based protein profiling.

Design, synthesis and evaluation of fluorinated CYP1B1 inhibitors based on a trans-stilbene scaffold.

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

A novel ring-opened ebselen scaffold with potent anti-angiogenic activity against cancer: synthesis, biological evaluation, and molecular docking.

SaBox/Cu(II)-catalyzed enantioselective Claisen rearrangement of 2-allyloxycyclohex-2-en-1-ones and 3-allyloxy-4H-chromenones.

Selective synthesis of phenylpropanoid carbonyl and diphenylalkyl derivatives via para-alkylation of tertiary anilines with cyclopropanol.

Single-Atom Ru on N-Heterocyclic Carbene-Functionalized Hypercrosslinked Polymers for N-Formylation of Amines with CO2 and H2.

Potential-regulated CO migration and CC bond formation on a co single-atom/Fe3 cluster tandem catalyst for CO2 electroreduction.

Selective Chlorination of Toluene and Halobenzenes Using Modified BaSO4-Supported Catalysts: A Sustainable Approach with (NH4)2S2O8 and H2O2 as Oxidants.

Palladium-Catalyzed Self- and Cross-Dimerization Annulation of β-CF3-1,3-Enynamides: An Access to Functionalized Bicyclo[4.2.0]trienes.

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Chemical genetics resulting from a passion for synthetic organic chemistry

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