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[Ultrastructural observation on the uncinate process of chronic sinusitis]
1Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical University, Wuhan.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|May 1, 1997
Summary
Scanning electron microscopy revealed damaged cilia and cell gaps in the uncinate processes of chronic sinusitis patients. These ultrastructural changes impair mucus transport, contributing to the disease, but nasal mucosa cells show repair potential.
Area of Science:
- Otorhinolaryngology
- Cell Biology
- Pathology
Context:
- Chronic sinusitis is a prevalent condition affecting the nasal passages.
- The uncinate processes (UP) play a crucial role in sinonasal physiology.
- Understanding the cellular basis of chronic sinusitis is essential for effective treatment.
Purpose:
- To investigate the ultrastructural changes in the uncinate processes of patients with chronic sinusitis.
- To correlate these morphological alterations with impaired sinonasal function.
- To assess the potential for repair in damaged nasal mucosa epithelial cells.
Summary:
- Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to examine uncinate processes from 16 chronic sinusitis patients.
- Observed ultrastructural changes included disordered cilia, increased intercellular gaps, squamous cell metaplasia, and mitochondrial/endoplasmic reticulum expansion.
- These findings indicate compromised mucus transport in the anterior ethmoid region and middle meatus, contributing to chronic sinusitis development.
Impact:
- The study highlights the significant role of ultrastructural damage in the pathogenesis of chronic sinusitis.
- It provides insights into the functional consequences of these cellular changes on mucus clearance.
- The findings suggest that damaged nasal mucosa epithelial cells possess reparable and reproducible capabilities, offering hope for therapeutic interventions.