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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Published on: February 14, 2017

Platelet hemostatic capacity (PHC) and fibrinolytic inhibitors during pregnancy

S Suzuki1, S Morishita

  • 1College of Medical Technology, Hokkaido University, Sapporo, Japan.

Seminars in Thrombosis and Hemostasis
|December 2, 1998
PubMed

Platelet hemostatic capacity (PHC) was measured in blood from pregnant patients during all three trimesters using the PFA-100 system. Closure times were shorter with both cartridge systems during pregnancy, compared to non-pregnant controls, suggesting increased PHC. Thrombin/antithrombin (TAT) complex and prothrombin fragment 1 + 2 (F 1+2) levels were elevated during pregnancy and increased over time. Also, plasma levels of plasminogen activator inhibitor 1 and 2 (PAI-1, PAI-2) increased during pregnancy. The data suggest increased coagulability during pregnancy. It is suggested that estrogen may play a role in this state of hypercoagulability. Seven days after delivery all of the measured parameters, except TAT levels, were again within normal range.

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