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Related Experiment Videos

The Signal Recognition Particle Database (SRPDB)

T Samuelsson1, C Zwieb

  • 1Department of Medical Biochemistry, University of Göteborg, Medicinareg. 9A, S-413 90, Göteborg, Sweden.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
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The Signal Recognition Particle Database (SRPDB) offers curated SRP RNA, protein, and receptor sequences for research. This resource provides aligned sequences, search motifs, and structural data for exploring SRP pathways.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Structural Biology

Background:

  • The Signal Recognition Particle (SRP) pathway is crucial for protein targeting to membranes.
  • Comprehensive sequence and structural data are essential for understanding SRP function.
  • Existing databases may lack integrated information on SRP components.

Purpose of the Study:

  • To establish and maintain a centralized database for Signal Recognition Particle (SRP) components.
  • To provide researchers with easy access to annotated SRP RNA, protein, and receptor sequences.
  • To facilitate the study of SRP evolution and function through phylogenetic and structural analysis.

Main Methods:

  • Compilation and curation of SRP RNA, SRP protein, and SRP receptor sequences from public databases.

Related Experiment Videos

  • Annotation of sequences with links to primary sources.
  • Organization of sequences alphabetically and phylogenetically.
  • Generation of aligned sequence data.
  • Inclusion of conserved sequence motifs and structural information (secondary structure diagrams, 3-D models).

    • Main Results:

    • The Signal Recognition Particle Database (SRPDB) houses 108 SRP RNA, 83 SRP protein, and 28 SRP receptor alpha subunit sequences as of September 1998.
    • Sequences are available in aligned formats, ordered alphabetically or phylogenetically.
    • The database includes search motifs and structural representations of SRP RNA.
    • Data is freely accessible online.

    Conclusions:

    • The SRPDB serves as a valuable, freely accessible resource for researchers studying the Signal Recognition Particle system.
    • Integrated sequence, motif, and structural data aids in understanding SRP-mediated protein targeting.
    • The database supports comparative analysis and exploration of SRP component evolution.