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Related Experiment Videos

Contemporary approaches to protein structure classification

M B Swindells1, C A Orengo, D T Jones

  • 1Helix Research Institute, Kisarazu, Japan.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 1, 1999
PubMed
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Comparing three-dimensional protein structures reveals distant evolutionary relationships missed by sequence analysis. This review covers popular methods, database searching applications, and advanced protein structure classifications.

Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Protein science

Background:

  • Sequence analysis is standard for protein comparisons.
  • Structural similarity can indicate distant evolutionary links.
  • Sequence-based methods may miss remote homology.

Purpose of the Study:

  • To review popular protein structure comparison methods.
  • To explain their use in database searching.
  • To describe advanced protein structure classification efforts.

Main Methods:

  • Summarizing popular three-dimensional protein structure comparison techniques.
  • Illustrating structure comparison for database searching.
  • Detailing advanced protein structure classification systems.

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Main Results:

  • Structural comparison identifies evolutionary relationships beyond sequence homology.
  • Enables creation of fold libraries for structure prediction.
  • Aids in estimating the diversity of protein folds.
  • Investigates structural preferences in protein evolution.

Conclusions:

  • Protein structure comparison is a powerful tool for uncovering deep evolutionary connections.
  • It facilitates structure prediction and understanding protein fold diversity.
  • Structural analysis provides insights into evolutionary constraints and preferences.