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Synthesis of protected guanidinium linked dinucleoside incorporable into an oligonucleotide using solid phase DNA
D A Barawkar1, B Linkletter, T C Bruice
1Department of Chemistry, University of California, Santa Barbara 93106, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The synthesis of novel fully protected guanidinium linked dinucleoside for incorporation into oligonucleotide using solid-phase DNA synthesis methodology was developed. The three different protecting groups selected allow different deprotection conditions.