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Updated: Jul 26, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Development of CD4+ effector T cells and susceptibility to infectious diseases
R M Locksley1, D J Fowell, K Shinkai
1Department of Medicine, University of California, San Francisco 94143-0654, USA. rich_locksley@quickmail.ucsf.edu
Abstract:
The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using Leishmania major infection of mice have revealed genetic contributions to factors that influence this differentiative process. Further, antigen recognition at the level of the T cell repertoire can also profoundly affect the outcome of disease and the appearance of discrete T cell subsets. It is likely that such mechanisms also underpin genetic susceptibility to diverse other infectious and autoimmune diseases.
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