Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal hyperinsulinism

V M Schwitzgebel1, S E Gitelman

  • 1Department of Pediatrics, University of California at San Francisco, USA.

Clinics in Perinatology
|January 19, 1999
PubMed
Summary
This summary is machine-generated.

Hyperinsulinism, a common cause of severe infant hypoglycemia, requires prompt diagnosis and treatment to prevent neurological damage. Recent research advances our understanding of its molecular causes and clinical management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Transition in diabetology].

Revue medicale suisse·2015
Same author

Widespread intracranial calcifications in the follow-up of a patient with cartilage-hair hypoplasia--anauxetic dysplasia spectrum disorder: a coincidental finding?

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2015
Same author

Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial.

Diabetologia·2012
Same author

Analysis of the duplicated human C4/P450c21/X gene cluster.

The Journal of steroid biochemistry and molecular biology·2012
Same author

Modeling intrauterine growth retardation in rodents: Impact on pancreas development and glucose homeostasis.

Molecular and cellular endocrinology·2009
Same journal

Breathing Physiology into the Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

The Science and Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

Ex Utero Artificial Womb Support: Promising Future for Extremely Preterm Infants.

Clinics in perinatology·2026
Same journal

Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia.

Clinics in perinatology·2026
Same journal

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.

Clinics in perinatology·2026
Same journal

Modern Surfactant Delivery Methods with a Focus on Implementation of Surfactant Administration Through Laryngeal and Supraglottic Airways.

Clinics in perinatology·2026
See all related articles

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Medicine
  • Molecular Pathophysiology

Background:

  • Hyperinsulinism is the primary cause of persistent hypoglycemia in neonates and infants.
  • Neurologic sequelae can result from delayed diagnosis and inadequate treatment.
  • Understanding molecular and cellular mechanisms is crucial for effective management.

Purpose of the Study:

  • To review the latest advancements in hyperinsulinism pathophysiology.
  • To discuss clinical features and diagnostic hallmarks.
  • To outline current and emerging treatment strategies.

Main Methods:

  • Review of current literature on hyperinsulinism.
  • Analysis of molecular and cellular mechanisms.
  • Synthesis of clinical presentation and diagnostic criteria.

Related Experiment Videos

  • Evaluation of treatment options.

    • Main Results:

    • Hyperinsulinism presents diverse molecular and cellular derangements.
    • Key clinical features and diagnostic indicators are identified.
    • Various therapeutic approaches exist, from medical to surgical.

    Conclusions:

    • Early diagnosis and aggressive treatment of hyperinsulinism are vital for preventing adverse neurologic outcomes.
    • Advances in understanding pathophysiology inform improved clinical management.
    • Multifaceted treatment strategies are essential for managing this complex condition.