Related Experiment Videos
Transgenic mice expressing Alzheimer amyloid precursor proteins
1Department of Neurology, University of Minnesota, Minneapolis 55455, USA. hsiao005@maroon.tc.umn.edu
Experimental Gerontology
|February 10, 1999
Summary
Transgenic mice expressing the Alzheimer amyloid precursor protein (APP) gene model key Alzheimer's disease features like memory loss and amyloid plaques. However, no single mouse model perfectly replicates all neuropathological aspects of the human disease.
Area of Science:
- Neuroscience
- Genetics
- Pathology
Background:
- The Alzheimer amyloid precursor protein (APP) gene was identified nearly a decade ago.
- Transgenic mouse models are crucial for studying complex neurological disorders like Alzheimer's disease.
Purpose of the Study:
- To summarize existing transgenic mouse models that express the Alzheimer amyloid precursor protein (APP).
- To highlight the behavioral and pathological features of Alzheimer's disease simulated in these mouse models.
Main Methods:
- Review and synthesis of published research on transgenic mice expressing APP.
- Analysis of reported behavioral deficits and neuropathological hallmarks in various mouse lines.
Main Results:
- Multiple transgenic mouse lines exhibit age-related learning and memory impairments.
- These models display varying degrees of neuronal loss, gliosis, neuritic changes, amyloid deposition, and abnormal tau phosphorylation.
- No single mouse model fully recapitulates all neuropathological features of Alzheimer's disease.
Conclusions:
- Transgenic mice expressing APP offer valuable insights into Alzheimer's disease mechanisms.
- The necessity of a complete neuropathological simulation for understanding neural dysfunction remains an open question.
- This article provides a summary of current Alzheimer's disease mouse models.