Brian T Hopkins

6PUBLICATIONS
14CO-AUTHORS
Biologically active moleculesCardiology (incl. cardiovascular diseases)Gene and molecular therapyProteins and peptidesAutoimmunity
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Publications (6)

|Apr 07, 2026
Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.

Brian T Hopkins, Isaac E Marx, Harlod George Vandeveer

|Feb 09, 2026
Involvement of Btk in Cardiovascular Disease and Its Therapeutic Targeting.

Philipp von Hundelshausen, Wolfgang Siess, Rundan Duan

|May 07, 2024
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.

Martin K Himmelbauer, Bekim Bajrami, Rebecca Basile

|Mar 12, 2024
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-<i>N</i>-(6-methylpyrazolo[1,5-<i>a</i>]pyrimidin-3-yl)imidazo[1,2-<i>a</i>]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.

Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach

|Apr 22, 2022
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.

Tricia L May-Dracka, Fang Gao, Brian T Hopkins

|Nov 04, 2021
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.

Brian T Hopkins, Eris Bame, Bekim Bajrami

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Frequent Collaborators

3 joint publications

Bin Ma

2 joint publications

Emily A Peterson

2 joint publications

Cathy A Muste

2 joint publications

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