John Krais

11PUBLICATIONS
56CO-AUTHORS
Cancer diagnosisMolecular targetsCancer therapy (excl. chemotherapy and radiation therapy)MechanobiologyCancer cell biology
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Publications (11)

|Jun 19, 2026
ATF4 coordinates amino acid and nucleotide synthesis with selective protein translation to ensure proper DNA replication timing in leukemia cells.

|Oct 03, 2025
Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model.

Yukihide Ota, Vijayalaxmi Gupta, Bisiayo E Fashemi

|Aug 14, 2024
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM.

Fumiaki Ito, Ziyuan Li, Leonid Minakhin

|Apr 05, 2024
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.

William Fried, Mrityunjay Tyagi, Leonid Minakhin

|Dec 08, 2023
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.

Marissa L Calbert, Gurushankar Chandramouly, Clare M Adams

|Nov 24, 2023
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.

John J Krais, David J Glass, Ilse Chudoba

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Frequent Collaborators

5 joint publications

Neil Johnson

4 joint publications

Richard T Pomerantz

3 joint publications

Marissa L Calbert

2 joint publications

Xiaojiang S Chen