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James Smith

4PUBLICATIONS

19CO-AUTHORS

Gene and molecular therapyMolecular targetsCheminformatics and quantitative structure-activity relationships

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Publications (4)

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|May 22, 2026

Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation.

|Jul 31, 2024

Discovery and <i>In Vivo</i> Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.

James M Smith, Bernard Barlaam, David Beattie

|Mar 11, 2024

Development of a Series of Pyrrolopyridone MAT2A Inhibitors.

Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou

|Apr 26, 2021

Fragment-Based Design of a Potent MAT2a Inhibitor and <i>in Vivo</i> Evaluation in an MTAP Null Xenograft Model.

Claudia De Fusco, Marianne Schimpl, Ulf Börjesson

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Frequent Collaborators

4 joint publications

Graeme Robb

3 joint publications

James S Scott

2 joint publications

Claudia De Fusco

2 joint publications

Marianne Schimpl

2 joint publications

David Wagner

2 joint publications

Argyrides Argyrou

2 joint publications

Elisabetta Chiarparin

2 joint publications

Bernard Barlaam

2 joint publications

Sophie L Cooke

2 joint publications

Judit É Debreczeni

Frequent Collaborators

4 joint publications

Graeme Robb

3 joint publications

James S Scott

2 joint publications

Claudia De Fusco

2 joint publications

Marianne Schimpl