Nicole Machado

6PUBLICATIONS
44CO-AUTHORS
Molecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Haematological tumoursRadiation therapyMedical biochemistry - proteins and peptides (incl. medical proteomics)
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Publications (6)

|Jun 12, 2026
SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.

|Apr 30, 2026
Structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors to modify tumour hypoxia.

|Jul 22, 2025
UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment.

Tatsuya Suwa, Kelly Sw Lee, Ian J Chai

|Feb 26, 2025
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades.

Ameya R Kirtane, Jianling Bi, Netra U Rajesh

|Aug 10, 2023
Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities.

Nicole D Machado, Lisa C Heather, Adrian L Harris

|Jan 23, 2023
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Gonzalo Rodriguez-Berriguete, Marco Ranzani, Remko Prevo

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Frequent Collaborators

4 joint publications

Geoff S Higgins

4 joint publications

Gonzalo Rodriguez-Berriguete

2 joint publications

Ester M Hammond

2 joint publications

Marco Ranzani