Doyle J Cassar

6PUBLICATIONS
26CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesBiomolecular modelling and design
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Publications (6)

|Jun 16, 2026
Discovery of CNS Penetrant SOS1 Inhibitors for the Treatment of KRAS-Dependent Cancers.

|Jan 30, 2026
Discovery of AZD9750, an Orally Bioavailable Androgen Receptor Degrader for the Treatment of Prostate Cancer.

James S Scott, Laura Evans, Peter C Astles

|Jul 11, 2024
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

Sharan K Bagal, Peter C Astles, Coura Diène

|Jun 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1.

Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell

|Jul 03, 2023
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.

Jason G Kettle, Sharan K Bagal, Derek Barratt

|Apr 26, 2022
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.

Jason G Kettle, Sharan K Bagal, Sue Bickerton

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Frequent Collaborators

4 joint publications

Jason G Kettle

3 joint publications

Michael S Bodnarchuk

3 joint publications

Coura R N Diène

3 joint publications

Sharan K Bagal