Jonathan T Seal

7PUBLICATIONS
38CO-AUTHORS
Molecular targetsBiologically active molecules
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Publications (7)

|Jun 11, 2025
Depleting the Action of EZH2 through PI3K-mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer.

Michelle Melino, Wen Juan Tu, Helle Bielefeldt-Ohmann

|Jan 07, 2022
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.

Philip G Humphreys, Stephen J Atkinson, Paul Bamborough

|Jul 13, 2021
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

Jonathan T Seal, Stephen J Atkinson, Paul Bamborough

|Jul 07, 2021
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.

Lee A Harrison, Stephen J Atkinson, Anna Bassil

|Mar 04, 2021
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

Helen E Aylott, Stephen J Atkinson, Paul Bamborough

|Jul 24, 2020
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.

Jonathan T Seal, Stephen J Atkinson, Helen Aylott

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Frequent Collaborators

6 joint publications

Alex Preston

6 joint publications

Chun-Wa Chung

5 joint publications

Paul Bamborough

5 joint publications

Emmanuel H Demont