Paul Bamborough

22PUBLICATIONS
76CO-AUTHORS
Molecular targetsGenome structure and regulationCheminformatics and quantitative structure-activity relationshipsMedical devicesBiologically active molecules
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Publications (22)

|Dec 30, 2025
BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor.

Francesco Rianjongdee, Stephen J Atkinson, Paul Bamborough

|Jun 12, 2024
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.

David J Hirst, Paul Bamborough, Niam Al-Mahdi

|Sep 22, 2023
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.

Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin

|Nov 15, 2022
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.

Philip G Humphreys, Niall A Anderson, Paul Bamborough

|Jan 07, 2022
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.

Philip G Humphreys, Stephen J Atkinson, Paul Bamborough

|Dec 20, 2021
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Christopher R Wellaway, Ian R Baldwin, Paul Bamborough

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Frequent Collaborators

17 joint publications

Chun-Wa Chung

10 joint publications

Emmanuel H Demont

8 joint publications

Alex Preston

7 joint publications

Stephen J Atkinson