Alex Preston

12PUBLICATIONS
46CO-AUTHORS
Molecular targetsGenome structure and regulationCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesHaematological tumours
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Publications (12)

|Dec 30, 2025
BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor.

Francesco Rianjongdee, Stephen J Atkinson, Paul Bamborough

|Apr 16, 2025
Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold.

Jaffer M Zaidi, Eleonora Comeo, Andrew Baxter

|Sep 22, 2023
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.

Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin

|Jan 07, 2022
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.

Philip G Humphreys, Stephen J Atkinson, Paul Bamborough

|Jul 14, 2021
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.

Simon C C Lucas, Stephen J Atkinson, Chun-Wa Chung

|Jul 13, 2021
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

Jonathan T Seal, Stephen J Atkinson, Paul Bamborough

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Frequent Collaborators

10 joint publications

Chun-Wa Chung

9 joint publications

Emmanuel H Demont

8 joint publications

Stephen J Atkinson

8 joint publications

Paul Bamborough