Theresa Klett

7PUBLICATIONS
18CO-AUTHORS
Molecular targetsProteins and peptidesCheminformatics and quantitative structure-activity relationshipsHaematological tumoursBiomolecular modelling and design
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Publications (7)

|May 16, 2026
Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W.

|Jul 02, 2025
SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes.

Theresa Klett, Jason Stahlecker, Martin Schwer

|Dec 19, 2024
Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution.

Theresa Klett, Jason Stahlecker, Simon Jaag

|Jul 08, 2024
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53.

Theresa Klett, Martin Schwer, Larissa N Ernst

|May 02, 2023
Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4.

Sebastian Vaas, Markus O Zimmermann, Theresa Klett

|Dec 23, 2022
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C.

Jason Stahlecker, Theresa Klett, Martin Schwer

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Frequent Collaborators

7 joint publications

Frank M Boeckler

4 joint publications

Jason Stahlecker

4 joint publications

Michael Lämmerhofer

4 joint publications

Benedikt Masberg