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Jason Stahlecker

9PUBLICATIONS
23CO-AUTHORS
Biomolecular modelling and designMolecular targetsCheminformatics and quantitative structure-activity relationshipsProteins and peptidesOrganic chemical synthesis
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Journal

Publications (9)

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|May 25, 2026
Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue.

|May 16, 2026
Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W.

|Aug 11, 2025
Design, Synthesis, and Molecular Evaluation of S<sub>N</sub>Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode.

Larissa N Ernst, Jason Stahlecker, Finn Mier

|Jul 02, 2025
S<sub>N</sub>Ar Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes.

Theresa Klett, Jason Stahlecker, Martin Schwer

|Dec 19, 2024
Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution.

Theresa Klett, Jason Stahlecker, Simon Jaag

|Sep 18, 2024
Halogen Bonding on Water─A Drop in the Ocean?

Marc U Engelhardt, Markus O Zimmermann, Marcel Dammann

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Frequent Collaborators

8 joint publications

Frank M Boeckler

5 joint publications

Michael Lämmerhofer

4 joint publications

Theresa Klett

4 joint publications

Benedikt Masberg

3 joint publications

Thilo Stehle

3 joint publications

Marc U Engelhardt

3 joint publications

Martin Schwer

2 joint publications

Cornelius Knappe

2 joint publications

Murray Coles

2 joint publications

Markus O Zimmermann

Frequent Collaborators

8 joint publications

Frank M Boeckler

5 joint publications

Michael Lämmerhofer

4 joint publications

Theresa Klett

4 joint publications

Benedikt Masberg