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Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
Published on: November 16, 2015
[Clinical analysis of infectious mononucleosis misdiagnosised as tonsillitis]
1Department of Otolaryngology, Huaxi Hospital of Sichuan University, Chengdu, 610041, China. yongfeng33@sina.com
Insights
Infectious mononucleosis can be misdiagnosed as tonsillitis, especially in convalescent stages. Monitoring lymphocyte counts aids in accurate diagnosis of Epstein-Barr virus infections.
Area of Science:
- Infectious Diseases
- Virology
- Clinical Medicine
Context:
- Tonsillitis is a common diagnosis, but infectious mononucleosis (IM) can present with similar symptoms.
- Misdiagnosis of IM as tonsillitis can lead to delayed or inappropriate treatment.
Purpose:
- To discuss the clinical features of infectious mononucleosis (IM) that are often misdiagnosed as tonsillitis.
- To highlight diagnostic methods for differentiating IM from tonsillitis.
Summary:
- Six cases of IM misdiagnosed as tonsillitis were identified using variant lymphocyte counts, heterophil agglutination tests, and EBVCA-IgA detection.
- These patients recovered without complications such as upper airway obstruction.
Impact:
- Emphasizes the importance of considering IM in differential diagnoses for tonsillitis.
- Highlights that IM cases without hepatic or renal involvement, or in convalescence, are prone to misdiagnosis.
Objective:
Discussing the clinical features of infectious mononucleosis misdiagnosised as tonsillitis.
Method:
We used the methods of variant lymphocyte count, heterophil agglutination test and EBVCA-IgA detection to diagnose 6 cases of infectious mononucleosis misdiagnosised as tonsillitis.
Result:
Six cases of infectious mononucleosis misdiagnosised as tonsillitis are cured without upper airway obstruction.
Conclusion:
We must pay attention to the variant lymphocyte count when tonsillitis is diagnosed. Some cases of infectious mononucleosis in convalescence or without hepatic functional lesion and renal functional lesion are easily misdiagnosised and missed.
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