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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
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Diagnosis and treatment of Hodgkin's lymphoma: at times a challenge

Nadeem Zia Abbasi1, Mir Jalal-ud-Din, Zainab Zahur

  • 1Department of Oncology, Institute of Nuclear Medicine, Oncology and Radiotherapy (INOR), Abbottabad.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|October 12, 2013
PubMed

Insights

This case report highlights an infrequent presentation of Hodgkin's lymphoma in sub-diaphragmatic lymph nodes causing obstructive jaundice. Early diagnosis and modified chemotherapy are crucial for effective treatment in rare Hodgkin's lymphoma cases.

Area of Science:

  • Oncology
  • Hematology
  • Gastroenterology

Background:

  • Hodgkin's lymphoma is typically characterized by Reed-Sternberg cells and commonly affects cervical/supraclavicular lymph nodes.
  • Sub-diaphragmatic lymphadenopathy is an uncommon presentation of Hodgkin's lymphoma.

Observation:

  • A 51-year-old female presented with obstructive jaundice and lymphadenopathy, initially misdiagnosed and treated for tuberculosis.
  • The patient's symptoms were attributed to an unusual presentation of Hodgkin's lymphoma.

Findings:

  • A modified ABVD chemotherapy protocol was administered with dose adjustments based on liver function tests (LFTs).
  • Liver function normalized after the first cycle of chemotherapy, indicating treatment efficacy.

Implications:

  • Emphasizes the importance of definitive diagnosis before initiating treatment for suspected Hodgkin's lymphoma.
  • Demonstrates the successful use of a modified chemotherapy regimen for an infrequent presentation of Hodgkin's lymphoma.

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