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Updated: Mar 14, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Lymphomas-Part 2
Lara A Brandão1, Mauricio Castillo2
1Radiologic Department, Clínica Felippe Mattoso, Fleury Medicina Diagnóstica, Avenida das Américas 700, sala 320, Barra Da Tijuca, Rio De Janeiro, Rio De Janeiro CEP 22640-100, Brazil; Radiologic Department, Clínica IRM- Ressonância Magnética, Rua Capitão Salomão, Humaitá, Rio De Janeiro, Rio De Janeiro CEP 22271-040, Brazil.
Insights
Central nervous system lymphoma presents diagnostic challenges due to variable imaging features influenced by immune status. Understanding appearances and mimics is crucial for accurate radiologist diagnosis.
Area of Science:
- Neurology
- Radiology
- Oncology
Background:
- Central nervous system (CNS) lymphoma encompasses primary and secondary types.
- Imaging features of CNS lymphoma are variable and pose diagnostic challenges.
- Patient immune status significantly impacts CNS lymphoma imaging findings.
Purpose of the Study:
- To discuss uncommon types of CNS lymphoma.
- To review the differential diagnosis for various patterns of CNS lymphoma.
- To aid radiologists in identifying CNS lymphoma and its mimics.
Main Methods:
- Review of imaging features of CNS lymphoma.
- Discussion of variations and mimics.
- Categorization of lymphomas by pattern (focal, multifocal, meningeal, infiltrative).
Main Results:
- CNS lymphoma imaging is complex and influenced by immune status.
- Special types like lymphomatosis cerebri, intravascular lymphoma, and lymphomatoid granulomatosis exist.
- Differential diagnosis requires familiarity with typical and atypical presentations.
Conclusions:
- Accurate diagnosis of CNS lymphoma requires awareness of its diverse imaging manifestations.
- Radiologists must consider lymphoma in the differential diagnosis for various intracranial lesions.
- Understanding uncommon lymphoma types and mimics improves diagnostic confidence.
Abstract:
There are 2 types of central nervous system lymphoma: primary and secondary. Both have variable imaging features making them diagnostic challenges. Furthermore, a patient's immune status significantly alters the imaging findings. Familiarity with typical appearances, variations, and common mimics aids radiologists in appropriately considering lymphoma in the differential diagnosis. Moreover, special types of lymphoma, such as lymphomatosis cerebri, intravascular lymphoma, and lymphomatoid granulomatosis, also are found. This article discusses uncommon types of lymphoma and the differential diagnosis for focal, multifocal, meningeal, and infiltrative lymphomas.
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