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Activación retardada de los sensores basada en recubrimientos transitorios: protección contra la bioincrustación en
Víctor Ruiz-Valdepeñas Montiel1,2, Juliane R Sempionatto1, Berta Esteban-Fernández de Ávila1
1Department of Nanoengineering , University of California, San Diego , La Jolla , California 92093 , United States.
Journal of the American Chemical Society
|October 19, 2018
Resumen
Los recubrimientos transitorios programables permiten la activación retrasada del sensor, superando la bioincrustación para el monitoreo continuo en fluidos complejos como la sangre y la saliva.
Área de la Ciencia:
- Ciencias de los materiales
- Ingeniería biomédica
- Tecnología de sensores
Sus antecedentes:
- La bioincrustación limita significativamente el rendimiento y la longevidad de los biosensores electroquímicos en fluidos biológicos complejos.
- Las tecnologías de sensores existentes luchan con el monitoreo continuo debido a la contaminación biológica y la necesidad de renovación frecuente de la superficie.
- La activación retrasada de las superficies de detección es deseable para superar estas limitaciones.
Objetivo del estudio:
- Desarrollar recubrimientos poliméricos transitorios para la exposición programada y retrasada de conjuntos de sensores de múltiples electrodos.
- Investigar las propiedades antiincrustantes y las capacidades de accionamiento secuencial sintonizables de estos recubrimientos.
- Demostrar la viabilidad de la monitorización directa de la glucosa en biofluidos no tratados utilizando el sistema de sensores retardados desarrollado.
Principales métodos:
- Fabricación de recubrimientos poliméricos transitorios con densidad y grosor adaptados.
- Caracterización de las velocidades de disolución del recubrimiento y activación secuencial de los electrodos de detección individuales.
- Aplicación del sistema de sensores retrasados para el control directo de la glucosa en muestras de sangre y saliva no tratadas.
Principales resultados:
- Los recubrimientos transitorios permitieron una exposición programable y retrasada de las superficies de los sensores frescos.
- Las propiedades de recubrimiento controladas permitieron la activación secuencial sintonizable de los electrodos de detección.
- El monitoreo directo de la glucosa en sangre y saliva no tratada se logró durante períodos prolongados con reducción de la bioincrustación.
Conclusiones:
- Los recubrimientos poliméricos transitorios ofrecen una estrategia viable para la activación retardada de los sensores y la prevención de la contaminación.
- El concepto desarrollado de exposición con sensores retrasados es muy prometedor para el funcionamiento continuo en fluidos biológicos complejos.
- Esta tecnología podría permitir aplicaciones de monitoreo in situ a largo plazo en el diagnóstico y la atención sanitaria.
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