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El Diseñador prueba su corazón enfermo y dividido
1Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Cell
|February 9, 2019
Resumen
Investigadores creados
Área de la Ciencia:
- Investigación cardiovascular
- Biotecnología
- Tecnología de células madre
Sus antecedentes:
- Los modelos in vitro actuales tienen limitaciones para replicar con precisión la fisiología del corazón humano.
- El desarrollo de fármacos requiere modelos fiables para evaluar la seguridad y eficacia terapéutica.
Objetivo del estudio:
- Desarrollar y validar nuevos "órganos en chips" para la investigación cardíaca.
- Crear una plataforma para probar la seguridad y la eficacia de los medicamentos utilizando células específicas del paciente.
Principales métodos:
- Utilizó células madre pluripotentes inducidas (iPSC) para generar tejidos cardíacos.
- Tejidos cardíacos derivados de iPSC integrados en dispositivos de sistemas microelectromecánicos (MEMS).
- Desarrollo de organoides cardíacos multicámara en chips.
Principales resultados:
- Replicó con éxito la estructura y función de diferentes cámaras cardíacas in vitro.
- Demostró la capacidad de modelar tejidos cardíacos sanos y enfermos.
- Validaron la plataforma para replicar las respuestas fisiológicas.
Conclusiones:
- Los "órganos en chips" cardíacos constituyen una nueva y poderosa herramienta para la investigación cardiovascular.
- Esta tecnología puede avanzar significativamente en las pruebas preclínicas de nuevas terapias.
- Ofrece una alternativa más precisa y ética a las pruebas tradicionales con animales.
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