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リンガンド誘発による形状の変化で,ヒトのテロメアDNAG-四重複素と結合すると,カチオン放出が発生する

Adrien Marchand1, Anton Granzhan, Keisuke Iida

  • 1IECB, ARNA Laboratory, University of Bordeaux , 33600 Pessac, France.

Journal of the American Chemical Society
|December 20, 2014
PubMed
まとめ

強力なリガンドは,ヒトのテロメアDNAのG-四重複構造を変化させることができます. この反パラレル形への形状転換は,リガンド設計における重要な要因であるカリウムイオンの除去を伴う.

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