トランジントコーティングによる遅延センサー活性化:複雑なバイオフリウイドにおけるバイオフォリング保護
Víctor Ruiz-Valdepeñas Montiel1,2, Juliane R Sempionatto1, Berta Esteban-Fernández de Ávila1
1Department of Nanoengineering , University of California, San Diego , La Jolla , California 92093 , United States.
Journal of the American Chemical Society
|October 19, 2018
まとめ
プログラム可能な一時的なコーティングにより センサーのアクティベーションが遅れて 血液や唾液などの複雑な液体の 継続的なモニタリングを可能にします
科学分野:
- 材料科学
- 生物医学工学
- センサー技術
背景:
- 生物汚染は,複雑な生物学的流体における電気化学バイオセンサの性能と長寿を著しく制限する.
- 既存のセンサー技術は 生物汚染による継続的なモニタリングと 頻繁な表面更新の必要性で苦戦しています
- これらの制限を克服するために,感知面の遅延が望ましい.
研究 の 目的:
- 多電極センサー配列のプログラム可能で遅延された曝露のための一時的なポリマーコーティングを開発する.
- これらのコーティングの抗生物汚染特性と調整可能な連続的なアクチュエーション能力を調査する.
- 開発された遅延センサーシステムを使用して,未処理の生物流体における直接的なグルコースモニタリングの実現可能性を実証する.
主な方法:
- 密度と厚さに合わせて変形性ポリマーコーティングの製造.
- コーティング溶解率の特徴と個々のセンサー電極の連続的なアクチュエーション.
- 治療されていない血液と唾液のサンプルにおける直接的なグルコースモニタリングのための遅延センサーシステムの適用
主要な成果:
- 新鮮なセンサ表面のプログラム可能な時間遅れの曝露を可能にしました.
- コントロールされたコーティング特性により,センサー電極の順次アクチュエーションが可能です.
- 未処理の血液と唾液における直接的な血糖モニタリングは,生物汚染が減少した長期間にわたって達成された.
結論:
- 暫定的なポリマーコーティングは 遅延したセンサーの起動と 生物汚染の防止に有効な戦略です
- 開発された遅延センサー曝露コンセプトは,複雑な生物学的流体での継続的な動作に大きな希望を示しています.
- この技術により 診断や医療における 長期のインサイトモニタリングが可能になります
関連する概念動画
Transmission-based Precautions II: Airborne and Protective Environment
1.9K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.9K
Protein Complex Assembly
16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Series R—L Circuit Transients
397
In a series resistor-inductor (R-L) circuit, closing the switch at the start of the time period simulates a three-phase short circuit, a fault condition where all three phases of an unloaded synchronous machine are short-circuited. When there is no fault impedance and no initial current, the initial voltage is determined by the phase angle of the source voltage.
Using Kirchhoff's Voltage Law (KVL) to analyze this circuit helps determine the total asymmetrical fault current, which consists...
Using Kirchhoff's Voltage Law (KVL) to analyze this circuit helps determine the total asymmetrical fault current, which consists...
397
Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
Zones of Protection
798
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
798
Radial System Protection
443
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
443


