病気 で 分裂 し た 心 の ため に 設計 者 が 試し て いる
1Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Cell
|February 9, 2019
まとめ
研究者作成
科学分野:
- 心血管研究
- バイオテクノロジー
- 幹細胞技術
背景:
- ヒトの心臓の生理学を正確に複製する現行のin vitroモデルには限界があります.
- 薬の開発には 治療の安全性と有効性を評価するための 信頼性の高いモデルが必要です
研究 の 目的:
- 心臓研究のための新しい"臓器チップ"の開発と検証
- 患者特有の細胞を使って 薬の安全性と有効性を テストするプラットフォームを 作り出すこと
主な方法:
- 誘発性多能幹細胞 (iPSC) を用いて心臓組織を生成した.
- マイクロ電気機械システム (MEMS) 装置に統合されたiPSC由来心臓組織.
- チップ上に多室の心臓器官を開発した.
主要な成果:
- 異なる心臓室の構造と機能を vitroで成功裏に複製した.
- 心臓の健康な組織と 病気の組織の両方を モデル化する能力を示した.
- 生理学的反応を再現するための プラットフォームを検証した
結論:
- 心臓の"臓器チップ"は 心血管研究のための強力な新しいツールです
- この技術は 新種の治療薬の臨床前試験を 大きく前進させることができます
- 伝統的な動物実験に より正確で倫理的な代替手段を 提供しています
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